Which of the following best describes a sign of hypoxia?

Cool, clammy skin is a classic sign of hypoxia. When the body is not receiving enough oxygen, one of the physiological responses can be vasoconstriction, particularly in the peripheries, which leads to cooler and oftentimes more clammy skin. This response is part of the body’s effort to redirect blood flow to vital organs, resulting in a decrease in skin temperature and moisture. In hypoxic conditions, the sympathetic nervous system is activated, which can induce these physical changes.

The other options do not directly indicate hypoxia. Increased blood pressure may not be a definitive signal of hypoxia, as blood pressure changes can result from various factors and may not specifically relate to oxygen levels. Wheezing may indicate respiratory distress or obstruction but does not signify hypoxia by itself. Flushed skin generally indicates increased blood flow, not a lack of oxygen, making it an unlikely representation of hypoxia.